Unveiling a Rare Neurological Case: Granulomatous Amebic Encephalitis Caused by Entamoeba dispar




In a groundbreaking case report published in the Journal of Biomedical Research & Environmental Sciences, researchers from Sun Yat-Sen University, China, have documented a rare instance of Granulomatous Amebic Encephalitis (GAE) in a young child caused by Entamoeba dispar — a microorganism previously considered non-pathogenic.

🔗 Read Full Article: Granulomatous Amebic Encephalitis Caused by Entamoeba dispar 

📌 Case Summary

A 4-year-old immunocompetent boy presented with progressive esotropia in the left eye. Surprisingly, magnetic resonance imaging (MRI) revealed multiple heterogeneous lesions in several brain regions. Subsequent stereotactic biopsy and cerebrospinal fluid analysis using Next-Generation Sequencing (NGS) identified E. dispar DNA sequences — a finding that challenges conventional views on its pathogenic potential.

🧠 Diagnostic and Therapeutic Insights

  • Histopathology: Showed granulomatous inflammation with amoebic cysts and trophozoites.
  • Treatment: The child responded positively to three courses of metronidazole, with MRI showing lesion regression over several months.
  • Significance: This is possibly the first documented case of GAE linked to E. dispar, prompting a reassessment of its role in CNS infections.

🔍 Why It Matters

Historically considered non-pathogenic, Entamoeba dispar may now join the list of rare causes of GAE, especially in pediatric patients. The use of NGS in this diagnosis exemplifies the growing relevance of precision diagnostics in infectious neurology.

"If you are ready to proceed, please submit your manuscript as an email attachment to: myra.r@scireslit.us  or myrarory.srl@gmail.com."






#GranulomatousAmebicEncephalitis
#EntamoebaDispar
#CNSInfections
#RareCaseReport
#PediatricEncephalitis
#MedicalMicrobiology
#ParasiticInfections
#BrainHealth
#NGSDiagnostics
#BiomedicalResearch





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